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Reading: Hotel Six Four, Mayo Blvd will bring 257 rooms to north Phoenix healthcare corridor
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Hispanic Business TV > Phoenix > Hotel Six Four, Mayo Blvd will bring 257 rooms to north Phoenix healthcare corridor
Phoenix

Hotel Six Four, Mayo Blvd will bring 257 rooms to north Phoenix healthcare corridor

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Last updated: November 11, 2026 12:27 am
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A new dual-branded Hilton hotel with 257 rooms is coming to north Phoenix, just down the road from the Mayo Clinic campus.

The project is formally known as Hotel Six Four, Mayo Blvd. It will be built in a growing business and healthcare corridor at the southeast corner of 64th Street and Mayo Boulevard.

Plaza Companies and Fayth Hospitality are teaming up on the project, which will offer guests the choice of Hilton’s Tapestry Collection boutique brand or Homewood Suites extended-stay concept.

Mayo Clinic is just one of several nearby medical facilities. The ASU Health Futures Center, Brooks Rehabilitation Hospital and the Mayo Clinic’s Discovery Oasis expansion project are also in the area.

“We care for patients who come to Phoenix from across the country and around the world, often accompanied by family members and caregivers,” Dr. Richard Gray, CEO of Mayo Clinic in Arizona, said in a recent news release. “Convenient lodging, dining and other nearby services is an important part of supporting those patients and families while they are away from home.”

What amenities will Hotel Six Four, Mayo Blvd have?

Hotel amenities will include a pool, a gym, meeting space and a signature first-floor restaurant operated by New York-based Renwick Hospitality Group.

The location is just south of the Loop 101 Pima Freeway, close to shopping and entertainment destinations in Scottsdale and at Phoenix’s Desert Ridge and High Street districts.

The Phoenix City Council approved rezoning and changes to existing plans in April.

“North Phoenix continues to attract significant investment in healthcare, business, housing and hospitality, creating new opportunities for residents and strengthening Phoenix’s economy,” Mayor Kate Gallego said. “Hotel Six Four, Mayo Blvd is a great example of the private investment helping transform this part of our city into a dynamic destination for visitors, businesses and residents.”

Plaza Companies and Fayth Hospitality previously teamed up on a dual-branded Hilton hotel at Park Central in midtown Phoenix.

“We’ve seen firsthand how the right hotel can become an important part of a larger commercial and healthcare ecosystem,” said Sharon Harper, chair and CEO of Plaza Companies.



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