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Hispanic Business TV > Sports > NFL > NFL DFS picks, Week 12: Daily Fantasy lineup advice for FanDuel, DraftKings
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NFL DFS picks, Week 12: Daily Fantasy lineup advice for FanDuel, DraftKings

HBTV
Last updated: November 23, 2025 9:16 am
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Top NFL DFS picks for Week 12How to set NFL DFS lineups for Week 12

Week 12 has arrived for NFL DFS players, and there are three matchups on the Sunday ‘main slate’ that feature an over/under of 50 points or higher. Lions vs. Giants, Colts vs. Chiefs and Patriots vs. Bengals will all be potential sources of major offense. NFL DFS lineups won’t feature Ja’Marr Chase (suspension), Joe Burrow (toe) or Jaxson Dart (concussion) this week, but big names like Amon-Ra St. Brown, Drake Maye and Patrick Mahomes are all in play. 

Which NFL DFS picks from those matchups should you target, and are there players from potentially lower-scoring games like Seahawks vs. Titans or Raiders vs. Browns who should factor into your NFL DFS strategy? Before making any NFL DFS picks for Week 12, be sure to check out the NFL DFS advice, strategy, and stacks from SportsLine daily Fantasy expert Mike McClure. 

New users can also target the latest Underdog promo code, good for $100 in bonus entries when you play $5 with the promo code CBSSPORTS2 in select states.

McClure is a legendary professional DFS player with more than $2 million in career winnings. He uses a powerful prediction model that simulates every snap of NFL action, taking factors such as matchups, statistical trends, and injuries into account. This allows him to find the best DFS values that he shares only with members at SportsLine. His methodology has led to enormous cashes on FanDuel and DraftKings, including. In 2023, he finished tied for first in the DraftKings Millionaire Maker twice and the FanDuel Million once. Anyone who has followed him could be way up.

Now, McClure has turned his attention to Week 12’s Sunday main slate and just locked in his top daily Fantasy football picks. You can only see his picks and analysis at SportsLine. 

New users can target the DraftKings promo code, which offers $200 in bonus bets if your bet wins + 3 months of NBA League Pass:

Top NFL DFS picks for Week 12

Part of McClure’s NFL DFS strategy for the Week 12 main slate is rostering Chiefs tight end Travis Kelce at $5,000 on DraftKings and $6,000 on FanDuel. Generally the most expensive tight end in the player pool in recent years, Kelce is now the third-most expensive TE option on the main slate for both sites as his overall production has slipped. McClure, however, is encouraged by his massive numbers last week that included season highs in targets (13), receptions (9) and yards (91). The Colts rank 30th in the league in points given up to opposing Fantasy tight ends, opening the door for a massive day for Kelce in what could be a high-scoring game. See who else to roster at SportsLine.

Another one of McClure’s NFL DFS picks is Packers running back Emanuel Wilson ($6,500 on FanDuel, $5,300 on DraftKings), who could see a big workload with Josh Jacobs (knee) listed as questionable. Wilson, a third-year pro out of Fort Valley State, did a nice job in relief last week with 49 scrimmage yards and a score. He was also effective against the Steelers last month in the other game he saw extensive action, piling up 87 scrimmage yards. Minnesota has given up the ninth-most rushing yards to opposing backs this year and the Vikings might not have starting edge Jonathan Greenard (shoulder, questionable). See more NFL DFS picks at SportsLine.

New users can also check out the latest FanDuel promo code and get $150 in bonus bets at FanDuel if your $5 bet wins. 

How to set NFL DFS lineups for Week 12

McClure is targeting another undervalued player who could explode for huge numbers on Sunday. This pick could be the difference between winning your tournaments and cash games or going home with nothing. You can only see who it is, and the rest of McClure’s NFL DFS picks, at SportsLine.

So who is Mike McClure including in his optimal NFL DFS lineups for Sunday, and which under-the-radar player offers huge value? Visit SportsLine now to see optimal NFL DFS picks, NFL DFS rankings, NFL DFS advice and NFL DFS stacks, all from a daily Fantasy expert with more than $2 million in winnings, and find out. 





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