Why Gennaro picked the Colts: With an NFL-worst point differential of -96, Tennessee has been a brutal watch in 2025. Thus explains the head coach getting fired six weeks into his second season. It’s been rough, but the Titans have featured one diamond: DT Jeffery Simmons. In the first six weeks of this season, Simmons easily played the most snaps of any interior defensive lineman (320, per Next Gen Stats), racking up top-two marks at the position in sacks (4.5), QB pressures (23), tackles (28) and stops (23). On an overmatched team with a rookie quarterback and porous defense, Simmons often felt like the only thing saving Tennessee from complete oblivion — until this past Sunday’s game against New England, when the 6-4, 305-pounder suffered a hamstring injury in the first quarter. The Titans led 10-3 when Simmons left the game, but the Patriots went on to palindrome the home team, 31-13. Simmons didn’t practice on Wednesday, with interim head coach Mike McCoy calling him “week to week.” That leads me to surmise he’ll miss this game against the Colts — who, by the way, boast the league’s best point differential at +92. Indianapolis already beat this Titans team by three touchdowns in Nashville, and that was with Simmons in the lineup. So, what should we expect this time around, with the Colts playing in the comfy confines of Lucas Oil Stadium and Simmons nursing a bad hammy? More juice for Jonathan Taylor‘s MVP campaign.
