The Week 7 college football odds board is full with games every day of the week from Wednesday through Saturday. The headliners come on Saturday with the latest Week 7 college football lines showing Alabama (-3) vs. Missouri, Oregon (-7.5) vs. Indiana, Ohio State (-15.5) vs. Illinois and Texas (-2.5) versus Oklahoma in Arch Manning’s induction into the Red River Rivalry. Additionally, two prestigious programs will clash with Michigan vs. USC, and the Trojans are favored by 2.5 points.
How should you make college football picks for those games, and what are the best spread, total and money-line picks to include in college football best bets? Before locking in any Week 7 college football picks, be sure to see the college football betting guide from legendary Vegas handicapper Bruce Marshall.
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For years Vegas-based Marshall was synonymous with The Gold Sheet, the famous sports betting newsletter. He has also won various handicapping titles and also is working on several book projects. Marshall crushed his 2024 college football betting picks, going 64-43 and returning more than 16 units, finishing the season as SportsLine’s top expert. Anyone following could have seen huge returns.
Now, using his Tech Corner technique that evaluates all the trends, Marshall has turned his attention to the latest college football odds for Week 7 and evaluated each matchup. You can head to SportsLine to see every pick.
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Top college football predictions for Week 7
One of the top college football picks Marshall is recommending for Week 7: He’s backing No. 14 Missouri (+3.5) to cover against No. 18 Alabama in a noon ET start on Saturday. He also likes the Over (52.5) in this SEC clash.
Since losing to Florida State in the opener, Alabama has rolled to four wins and four covers. Missouri, however, is unbeaten on the season, and Marshall has identified some key betting trends that point to Mizzou being in a good spot to at least keep this one within the number.
“Alabama romped in this one 34-0 last October, but that was at Tuscaloosa,” Marshall told SportsLine. “The Tide are just 2-5 both straight up and spread in their last seven away from Bryant-Denny Stadium. The Tigers are on an 8-2 spread surge since last year’s loss (that includes just missing as 44.5 vs UMass), and 7-4 as underdogs since 2023. Mizzou is also on an 8-2 over run since late 2024, and the Bama game last October.” Go to SportsLine to see all of Marshall’s picks.
How to make college football picks for Week 7
Marshall has evaluated every other matchup and he’s found a critical 12-5 trend in another Week 7 game. Get betting analysis for each matchup at SportsLine, and use promo code CHAMPIONSHIP to get your first month for $1.
So what college football picks can you make with confidence, and what alarming trend do you need to know about this week? Check out the latest college football odds below, then visit SportsLine to see which teams to back, all from the legendary Vegas expert who has won multiple handicapping titles and went 64-43 last season, and find out.
College football odds for Week 7 notable games
See full Week 7 college football picks, odds, predictions here
(odds subject to change)
Wednesday, Oct. 8
Missouri State vs. MTSU (+2.5, 50.5)
Liberty vs. UTEP (+2.5, 47.5)
Thursday, Oct. 9
Louisiana Tech vs. Kennesaw State (+6.5, 45.5)
East Carolina vs. Tulane (-6.5, 54.5)
Jacksonville State vs. Sam Houston (+7.5, 55.5)
Southern Miss vs. Georgia Southern (+2.5, 60.5)
Friday, Oct. 10
USF vs. North Texas (-1.5)
Rutgers vs. Washington (-10.5, 58.5)
Fresno State vs. Colorado State (+6.5, 45.5)
Saturday, Oct. 11
Pittsburgh vs. Florida State (-10.5, 57.5)
Alabama vs. Missouri (+3.5, 54.5)
Ohio State vs. Illinois (+15.5, 50.5)
Oklahoma vs. Texas (-3, 42.5)
Indiana vs. Oregon (-7.5, 54.5)
UCLA vs. Michigan State (-8.5, 55.5)
Iowa vs. Wisconsin (+3.5, 37.5)
Georgia vs. Auburn (+3.5, 46.5)
Michigan vs. USC (-2.5, 54.5)
LSU vs. South Carolina (+10, 44.5)
Arizona State vs. Utah (-5.5, 48.5)
