The Indianapolis Colts suffer their first loss, 27-20 to the Los Angeles Rams in NFL Week 4 action, and one player plays an unfortunate critical role.
Second-year receiver Adonai Mitchell fumbles the ball out of the end zone on what would have been a touchdown. He later commits holding, negating a long Jonathan Taylor touchdown run.
Daniel Jones completes 24-of-33 passes for 262 yards, 1 touchdown and 2 interceptions, both by Kam Curl. Taylor rushes for 76 yards. Taylor, Tyler Warren and Michael Pittman Jr. have 5 catches each, and Pittman scores the TD.
The Colts commit 11 penalties for 88 yards.
Matthew Stafford goes 29-of-41 for 375 yards and 3 touchdowns, including the winner in the closing minutes for his 50th career 4th-quarter winning drive. Puka Nacua has 13 catches for 170 yards and a TD. Kyren Williams has 77 rushing yards.
The Colts (3-1) host the Las Vegas Raiders in Week 5 action.
:53 left 4Q: The long pass intended for Michael Pittman Jr. is picked off.
Rams 27, Colts 20, 1:33 left 4Q: Matthew Stafford hits a wide-open Tutu Atwell for 88 yards on the first play of the drive. Atwell’s defender fell down on the play.
2:15 left 4Q: Adonai Mitchell commits holding, negating a 53-yard touchdown run by Jonathan Taylor.
Colts 20, Rams 20, 3:20 left 4Q: Puka Nacua gets a 9-yard touchdown from Matthew Stafford on 4th-and-2. Nacua has 13 catches for 170 yards.
Colts 20, Rams 13, 8:58 left 4Q: Spencer Shrader connects from 38 yards. Tyler Warren is called for pass interference on the first play of the drive.
11:22 left 4Q: New Colts signee Mike Hilton hits Rams running back Kyren Williams, and the Colts recover at the Rams’ 17.
Colts 17, Rams 13, 11:34 left 4Q: Daniel Jones hits Michael Pittman Jr. from 2 yards. That completes an 11-play, 90-yard drive that takes 6:07.
2:41 left 3Q: The Colts are starting at their 10 after a Rams punt, their fourth of the quarter. The Colts have punted twice in the quarter.
11:32 left 3Q: Adonai Mitchell loses the ball just before the end zone, and it rolls out the back. Rams ball and the Colts lose a 76-yard go-ahead touchdown.
Daniel Jones is 10-of-14 for 85 yards and an early interception. Tyler Warren has 3 catches for 30 yards and a rushing touchdown. Jonathan Taylor has just 5 carries for 25 yards.
Matthew Stafford is 16-of-24 for 174 yards and a late touchdown to Davante Adams. Puka Nacua has 7 catches for 112 yards. Kyren Williams has 7 carries for 55 yards. Joshua Karty has 2 field goals.
The Rams get the kickoff to start the second half.
Rams 13, Colts 10, :07 left 2Q: Matthew Stafford hits Davante Adams for a 10-yard score to complete a 96-yard drive. Laiatu Latu sacks Matthew Stafford. The Rams complete passes to Puka Nacua and Davante Adams to reach Colts territory.
2:14 left 2Q: The Colts pin the Rams at the 4. This is the first game the Colts have punted and committed a turnover.
Colts 10, Rams 6, 5:21 left 2Q: Joshua Karty connects from 37 yards. Under pressure, Matthew Stafford drops in a 31-yard completion to Puka Nacua into the red zone.
Colts 10, Rams 3, 12:17 left 2Q: Tyler Warren rushes in from 2 yards on 4th down. Something of a fullback play.
2:02 left 1Q: The Colts stuff Rams quarterback Matthew Stafford and take over at L.A.’s 45-yard line.
Colts 3, Rams 3, 4:55 left 1Q: The Colts commit consecutive penalties costing them 25 yards. Tyler Warren has 2 catches for 29 yards on the drive. Anthony Gould starts the drive with a 38-yard kickoff return.
Rams 3, Colts 0, 7:32 left 1Q: Joshua Karty kicks a 42-yard field goal. The drive is 11 plays and 57 yards.
12:39 left 1Q: Daniel Jones underthrows A.D. Mitchell, and Kam Curl intercepts. L.A. takes over at its 20. That’s the Colts’ first turnover this season.
The Indianapolis Colts and Los Angeles Rams will play at 4:05 p.m. ET Sunday, Sept. 28, 2025.
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The Indianapolis Colts and Los Angeles Rams will air on Fox at 4:05 p.m. ET Sunday, Sept. 28, 2025.
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- via BetMGM
- Favorite: Rams by 3.5 points
- Over/under: 49.5 total points
- Moneyline: Colts +155, Rams -190
- ESPN’s matchup predictor gives the Rams a 55.5% chance of winning.
(all times ET)
- Thursday, Sept. 25: Seattle Seahawks 23, Arizona Cardinals 20, (summary, box score)
- Sunday, Sept. 28: Minnesota Vikings vs. Pittsburgh Steelers in Dublin, 9:30 a.m., NFL Network (summary, box score)
- Sunday, Sept. 28: Washington Commanders at Atlanta Falcons, 1 p.m., CBS (summary, box score)
- Sunday, Sept. 28: New Orleans Saints at Buffalo Bills, 1 p.m., CBS (summary, box score)
- Sunday, Sept. 28: Cleveland Browns at Detroit Lions, 1 p.m., Fox (summary, box score)
- Sunday, Sept. 28: Tennessee Titans at Houston Texans, 1 p.m., CBS (summary, box score)
- Sunday, Sept. 28: Carolina Panthers at New England Patriots, 1 p.m., Fox (summary, box score)
- Sunday, Sept. 28: Los Angeles Chargers at New York Giants, 1 p.m., CBS (summary, box score)
- Sunday, Sept. 28: Philadelphia Eagles at Tampa Bay Buccaneers, 1 p.m., Fox (summary, box score)
- Sunday, Sept. 28: Indianapolis Colts at Los Angeles Rams, 4:05 p.m., Fox (summary, box score)
- Sunday, Sept. 28: Jacksonville Jaguars at San Francisco 49ers, 4:05 p.m., Fox (summary, box score)
- Sunday, Sept. 28: Baltimore Ravens at Kansas City Chiefs, 4:25 p.m., CBS (summary, box score)
- Sunday, Sept. 28: Chicago Bears at Las Vegas Raiders, 4:25 p.m., CBS (summary, box score)
- Sunday, Sept. 28: Green Bay Packers at Dallas Cowboys, 8:20 p.m., NBC, Peacock, Telemundo (summary, box score)
- Monday, Sept. 29: New York Jets at Miami Dolphins, 7:15 p.m., ESPN (summary, box score)
- Monday, Sept. 29: Cincinnati Bengals at Denver Broncos, 8:15 p.m., ABC (summary, box score)
- Week 1: Indianapolis Colts 33, Miami Dolphins 8, box score, stats
- Week 2: Colts 29, Denver Broncos 28, box score, stats
- Week 3: Colts 41, Tennessee Titans 20, box score, stats
- Week 4: Sunday, Sept. 28, at Los Angeles Rams, 4:05 p.m., Fox
- Week 5: Sunday, Oct. 5, vs. Las Vegas Raiders, 1 p.m., Fox
- Week 6: Sunday, Oct. 12, vs. Arizona Cardinals, 1 p.m., Fox
- Week 7: Sunday, Oct. 19, at Los Angeles Chargers, 4:05 p.m., CBS
- Week 8: Sunday, Oct. 26, vs. Tennessee Titans, 4:25 p.m., CBS
- Week 9: Sunday, Nov. 2, at Pittsburgh Steelers, 1 p.m., CBS
- Week 10: Sunday, Nov. 9, vs. Atlanta Falcons in Berlin, Germany, 9:30 a.m., NFL Network
- Week 11: Bye
- Week 12: Sunday, Nov. 23, at Kansas City Chiefs, 1 p.m., CBS
- Week 13: Sunday, Nov. 30, vs. Houston Texans, 1 p.m., CBS
- Week 14: Sunday, Dec. 7, at Jacksonville Jaguars, 1 p.m., CBS
- Week 15: Sunday, Dec. 14, at Seattle Seahawks, 4:25 p.m., CBS
- Week 16: Monday, Dec. 22, vs. San Francisco 49ers, 8:15 p.m., ESPN‘s “Monday Night Football”
- Week 17: Sunday, Dec. 28, vs. Jacksonville Jaguars, 1 p.m., Fox
- Week 18: Date TBD, at Houston Texans, time TBD, TBD
Joel A. Erickson covers the Colts all season. Get more coverage on IndyStarTV and with the Colts Insider newsletter.
