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The NFL Week 5 schedule begins with the Los Angeles Rams vs San Francisco 49ers on Thursday Night Football at the Rams’ SoFi Stadium on Oct. 2.
Here’s what you need to know before the Thursday Night Football game in NFL Week 5, including time, TV channel, streaming information, NFL Week 5 announcers, NFL Week 5 predictions, NFL Week 5 picks and NFL Week 5 odds for the game.
The Rams beat the Indianapolis Colts, 27-20, in their NFL Week 4 game.
The 49ers are coming off a 26-21 loss against the Jacksonville Jaguars.
Los Angeles is 3-1 on the season. San Francisco also enters the game with a 3-1 record.
NFL Week 5 picks: 49ers at Rams | Vikings vs Browns | Texans at Ravens | Dolphins at Panthers | Raiders at Colts | Giants at Saints | Cowboys at Jets | Broncos at Eagles | Titans at Cardinals | Buccaneers at Seahawks | Lions at Bengals | Commanders at Chargers | Patriots at Bills | Chiefs at Jaguars | The Republic’s score predictions
Watch 49ers at Rams on Amazon Prime Video
What time is Thursday Night Football?
The 49ers vs Rams NFL Week 5 Thursday Night Football game is scheduled to begin at 5:15 p.m. MST, 8:15 p.m. ET.
What channel is Thursday Night Football on?
The Thursday Night Football NFL Week 5 game between the 49ers and Rams is not on TV and is only available through streaming.
How can I stream Thursday Night Football?
The NFL Week 5 49ers at Rams Thursday Night Football game will stream exclusively on Amazon Prime Video.
Who are the announcers for Thursday Night Football?
Al Michaels will have the play-by-play call for the 49ers-Rams game in NFL Week 5, with Kirk Herbstreit as the analyst.
Who is the favorite in Thursday Night football odds?
The Rams are a 3.5-point favorite over the 49ers in NFL Week 5 odds for the game, courtesy of BetMGM Sportsbook.
Los Angeles is -220 on the moneyline, while San Francisco is +180.
The over/under (point total) is set at 47 points.
Who will win on Thursday Night Football?
The Arizona Republic is predicting a 27-24 win for the Rams over the 49ers in the Thursday Night Football showdown.
Other sites’ NFL Week 5 picks and NFL Week 5 predictions also favor the Rams to beat the 49ers on TNF today, although not everyone is taking Los Angeles to cover against San Francisco in the first game on the NFL Week 5 schedule.
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Reach Jeremy Cluff at jeremy.cluff@arizonarepublic.com. Follow him on X, formerly Twitter @Jeremy_Cluff.
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